Страница 170

13 Lamb, M. J. 1968. “Temperature and Lifespan in Drosophila”. Nature 220:808–9, https://doi.org/10.1038/220808a0; Aigaki, T., Ohba, S. 1984. “Effect of Mating Status on Drosophila virilis Lifespan”. Experimental Gerontology 19:267–78, https://doi.org/10.1016/0531–5565 (84) 90022–6; Chapman, T., Hutchings, J., Partridge, L. 1993. “No Reduction in the Cost of Mating for Drosophila melanogaster Females Mating with Spermless Males”. Proceedings of the Royal Society B: Biological Sciences 253:211–17, https://doi.org/10.1098/rspb.1993.0105; Chapman, T., Herndon, L. A., Heifetz, Y., Partridge, L., Wolfner, M. F. 2001. “The Acp26Aa Seminal Fluid Protein Is a Modulator of Early Egg Hatchability in Drosophila melanogaster”. Proceedings of the Royal Society B: Biological Sciences 268:1647–54, https://doi.org/10.1098/rspb.2001.1684; Rose, M. R. 1989. “Genetics of Increased Lifespan in Drosophila”. Bioessays 11:132–35, https://doi.org/10.1002/bies.950110505.

14 Clancy et al. 2001.

15 Tatar et al. 2001.

16 Hwangbo, D. S., Gersham, B., Tu, M. P., Palmer, M., Tatar, M. 2004. “Drosophila dFOXO Controls Lifespan and Regulates Insulin Signalling in Brain and Fat Body”. Nature 429:562–66.

17 Libina, N., Berman, J. R., Kenyon, C. 2003. “Tissue-Specific Activities of C. elegans DAF-16 in the Regulation of Lifespan”. Cell 115:489–502.

18 Broughton, S. J., et al. 2010. “DILP-Producing Median Neurosecretory Cells in the Drosophila Brain Mediate the Response of Lifespan to Nutrition”. Aging Cell 9:336–46, https://doi.org/10.1111/j.1474–9726.2010.00558.x.

19 Holzenberger, M., et al. 2003. “IGF-1 Receptor Regulates Lifespan and Resistance to Oxidative Stress in Mice”. Nature 421:182–87; Hsieh, C. C., DeFord, J. H., Flurkey, K., Harrison, D. E., Papaconstantinou, J. 2002. “Effects of the Pit1 Mutation on the Insulin Signaling Pathway: Implications on the Longevity of the Long-Lived Snell Dwarf Mouse”. Mechanisms of Ageing and Development 123:1245–55; Hsieh, C. C., DeFord, J. H., Flurkey, K., Harrison, D. E., Papaconstantinou, J. 2002. “Implications for the Insulin Signaling Pathway in Snell Dwarf Mouse Longevity: A Similarity with the C. elegans Longevity Paradigm”. Mechanisms of Ageing and Development 123:1229–44.

20 Holzenberger et al. 2003.

21 Bluher, M., Kahn, B. B., Kahn, C. R. 2003. “Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue”. Science 299:572–74.

22 Burks, D. J., et al. 2000. “IRS-2 Pathways Integrate Female Reproduction and Energy Homeostasis”. Nature 407:377–82, https://doi.org/10.1038/35030105.

23 Suh, Y., et al. 2008. “Functionally Significant Insulin-Like Growth Factor I Receptor Mutations in Centenarians”. Proceedings of the National Academy of Sciences of the USA 105:3438–42.

24 Hedges, C. P., Shetty, B., Broome, S. C., MacRae, C., Koutsifeli, P., Buckels, E. J., et al. 2023. “Dietary Supplementation of Clinically Utilized PI3K p110α Inhibitor Extends the Lifespan of Male and Female Mice”. Nature Aging, https://doi.org/10.1038/s43587-022-0349-y.

25 Murphy, C. T., et al. 2003. “Genes that Act Downstream of DAF-16 to Influence the Lifespan of Caenorhabditis elegans”. Nature 424:277–83.

26 Tepper, R. G., Ashraf, J., Kaletsky, R., Kleema

27 Furuyama, T., Nakazawa, T., Nakano, I., Mori, N. 2000. “Identification of the Differential Distribution Patterns of mRNAs and Consensus Binding Sequences for Mouse DAF-16 Homologues”. Biochemical Journal 349:629–34.

28 Lee, S. S., Ke

29 McElwee, J. J., Schuster, E., Blanc, E., Thomas, J. H., Gems, D. 2004. “Shared Transcriptional Signature in Caenorhabditis elegans Dauer Larvae and Long-Lived daf-2 Mutants Implicates Detoxification System in Longevity Assurance”. Journal of Biological Chemistry 279:44533–43.

30 Tepper et al. 2013. Ген pqm-1 был выявлен при скрининге чувствительности к пaрaквaту в середине 1990-х годов, но после этого его больше не изучaли.

31 Hsu, A. L., Murphy, C. T., Kenyon, C. 2003. “Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor”. Science 300:1142–45; Tullet, J. M., et al. 2008. “Direct Inhibition of the Longevity-Promoting Fact or SKN-1 by Insulin-like Signaling in C. elegans”. Cell 132:1025–38, https://doi.org/10.1016/j.cell.2008.01.030; Lapierre, L. R., et al. 2013. “The TFEB Orthologue HLH-30 Regulates Autophagy and Modulates Longevity in Caenorhabditis elegans”. Nature Communications 4:2267, https://doi.org/10.1038/ncomms3267; Riedel, C. G., et al. 2013. “DAF-16 Employs the Chromatin Remodeller SWI/SNF to Promote Stress Resistance and Longevity”. Nature Cell Biology 15:491–501, https://doi.org/10.1038/ncb2720.

32 Soukas, A. A., Kane, E. A., Carr, C. E., Melo, J. A., Ruvkun, G. 2009. “Rictor/TORC2 Regulates Fat Metabolism, Feeding, Growth, and Life Span in Caenorhabditis elegans”. Genes and Development 23:496–511, https://doi.org/10.11 01/gad.1775409; Oh, S. W., et al. 2005. “JNK Regulates Lifespan in Caenorhabditis elegans by Modulating Nuclear Translocation of Forkhead Transcription Factor/DAF-16”. Proceedings of the National Academy of Sciences of the USA 102:4494–99.

33 Berdichevsky, A., Viswanathan, M., Horvitz, H. R., Guarente, L. 2006. “C. elegans SIR-2.1 Interacts with 14-3-3 Proteins to Activate DAF-16 and Extend Life Span”. Cell 125:1165–77.

34 Tepper et al. 2013.

35 Perez, M. F., Francesconi, M., Hidalgo-Carcedo, C., Lehner, B. 2017. “Maternal Age Generates Phenotypic Variation in Caenorhabditis elegans”. Nature 552:106–9, https://doi.org/10.1038/nature25012.