Страница 172

59 Staats, S., et al. 2018. “Dietary Resveratrol Does Not Affect Life Span, Body Composition, Stress Response, and Longevity-Related Gene Expression in Drosophila melanogaster”. International Journal of Molecular Sciences 19:223, https://doi.org/10.3390/ijms19010223; Bass, T. M., Weinkove, D., Houthoofd, K., Gems, D., Partridge, L. 2007. “Effects of Resveratrol on Lifespan in Drosophila melanogaster and Caenorhabditis elegans”. Mechanisms of Ageing and Development 128:546–52, https://doi.org/10.1016/j.mad.2007.07.007; Pallauf, K., Rimbach, G., Rupp, P. M., Chin, D., Wolf, I. M. 2016. “Resveratrol and Lifespan in Model Organisms”. Current Medicinal Chemistry 23:4639–80, https://doi.org/10.2174/0929867323666161024151233.

60 Fernández, A. F., and Fraga, M. F., 2011. “The Effects of the Dietary Polyphenol Resveratrol on Human Healthy Aging and Lifespan”. Epigenetics 6:870–74, https://doi.org/10.4161/epi.6.7.16499; Bhullar, K. S., and Hubbard, B. P., 2015. “Lifespan and Healthspan Extension by Resveratrol”. Biochimica et Biophysica Acta 1852:1209–18, https://doi.org/10.1016/j.bbadis.2015.01.012.

61 Hirschey et al. 2009.

62 Greer and Brunet 2009.

63 Arriola Apelo, S. I., Lamming, D. W. 2016. “Rapamycin: An InhibiTOR of Aging Emerges from the Soil of Easter Island”. Journals of Gerontology, Series A, Biological Sciences and Medical Sciences 71:841–49, https://doi.org/10.1093/gerona/glw090.

64 Lamming, D. W. 2016. “Inhibition of the Mechanistic Target of Rapamycin (mTOR) – Rapamycin and Beyond”. Cold Spring Harbor Perspectives in Medicine 6: a025924, https://doi.org/10.1101/cshperspect. a025924; Lamming, D. W., Ye, L., Sabatini, D. M., Baur, J. A. 2013. “Rapalogs and mTOR Inhibitors as Anti-aging Therapeutics”. Journal of Clinical Investigation 123:980–89, https://doi.org/10.1172/JCI64099.

65 Vellai, T., et al. 2003. “Influence of TOR Kinase on Lifespan in C. elegans”. Nature 426:620, https://doi.org/10.1038/426620a.

66 Kapahi, P., et al. 2004. “Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway”. Current Biology 14:885–90, https://doi.org/10.1016/j.cub.2004.03.059.

67 Powers et al. 2006; Kaeberlein, M., et al. 2005b, “Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients”. Science 310:1193–96, https://doi.org/10.1126/science.1115535; Hansen et al. 2005.

68 Sheaffer, K. L., Updike, D. L., Mango, S. E. 2008. “The Target of Rapamycin Pathway Antagonizes pha-4/FoxA to Control Development and Aging”. Current Biology 18:1355–64, https://doi.org/10.1016/j.cub.2008.07.097.

69 Apfeld, J., O’Co

70 Soukas, A. A., Kane, E. A., Carr, C. E., Melo, J. A., Ruvkun, G. 2009. “Rictor/TORC2 Regulates Fat Metabolism, Feeding, Growth, and Life Span in Caenorhabditis elegans”. Genes and Development 23:496–511, https://doi.org/10.1101/gad.1775409.

71 Greer, E. L., et al. 2007. “An AMPK-FOXO Pathway Mediates Longevity Induced by a Novel Method of Dietary Restriction in C. elegans”. Current Biology 17:1646–56, https://doi.org/10.1016/j.cub.2007.08.047.

72 Greer, Brunet 2009.

73 Honjoh, S., Yamamoto, T., Uno, M., Nishida, E. 2009. “Signalling through RHEB-1 Mediates Intermittent Fasting-Induced Longevity in C. elegans”. Nature 457:726–30, https://doi.org/10.1038/nature07583.

74 Murphy, C. T., et al. 2003. “Genes that Act Downstream of DAF-16 to Influence the Lifespan of Caenorhabditis elegans”. Nature 424:277–83; Murphy, C. T., Lee, S. J., Kenyon, C. 2007. “Tissue Entrainment by Feedback Regulation of Insulin Gene Expression in the Endoderm of Caenorhabditis elegans”. Proceedings of the National Academy of Sciences of the USA 104:19046–50.

75 Lee, C. K., Klopp, R. G., Weindruch, R., Prolla, T. A. 1999. “Gene Expression Profile of Aging and Its Retardation by Caloric Restriction”. Science 285:1390–93.

76 Pletcher, S. D., et al. 2002. “Genome-wide Transcript Profiles in Aging and Calorically Restricted Drosophila melanogaster”. Current Biology 12:712–23.

77 McCarroll, S. A., et al. 2004. “Comparing Genomic Expression Patterns across Species Identifies Shared Transcriptional Profile in Aging”. Nature Genetics 36:197–204.

78 Pandit, A., Jain, V., Kumar, N., Mukhopadhyay, A. 2014. “PHA-4/FOXA-Regulated MicroRNA Feed Forward Loops during Caenorhabditis elegans Dietary Restriction”. Aging (Albany NY) 6:835–55, https://doi.org/10.18632/aging.100697.

79 Hou, L., et al. 2016. “A Systems Approach to Reverse Engineer Lifespan Extension by Dietary Restriction”. Cell Metabolism 23:529–40, https://doi.org/10.1016/j.cmet.2016.02.002.

80 Bishop, N. A., Guarente, L. 2007. “Two Neurons Mediate Diet-Restriction-Induced Longevity in C. elegans”. Nature 447:545–49, https://doi.org/10.1038/nature05904.

81 Burkewitz, K., et al. 2015. “Neuronal CRTC-1 Governs Systemic Mitochondrial Metabolism and Lifespan via a Catecholamine Signal”. Cell 160:842–55, https://doi.org/10.1016/j.cell.2015.02.004.

82 Owen, B. M., et al. 2013. “FGF21 Contributes to Neuroendocrine Control of Female Reproduction”. Nature Medicine 19:1153–56, https://doi.org/10.1038/nm.3250.

83 Bookout, A. L., et al. 2013. “FGF21 Regulates Metabolism and Circadian Behavior by Acting on the Nervous System”. Nature Medicine 19:1147–52, https://doi.org/10.1038/nm.3249; Talukdar, S., et al. 2016. “FGF21 Regulates Sweet and Alcohol Preference”. Cell Metabolism 23:344–49, https://doi.org/10.1016/j.cmet.2015.12.008.

84 Zhang, Y., et al. 2012. “Liver LXRalpha Expression is Crucial for Whole Body Cholesterol Homeostasis and Reverse Cholesterol Transport in Mice”. Journal of Clinical Investigation 122:1688–99, https://doi.org/10.1172/JCI59817.

85 Hansen et al. 2007; Kaeberlein et al. 2005b; Hamilton, B., et al. 2005. “A Systematic RNAi Screen for Longevity Genes in C. elegans”. Genes and Development 19:1544–55.

86 Wu, J., et al. 2018. “PHA-4/FoxA Senses Nucleolar Stress to Regulate Lipid Accumulation in Caenorhabditis elegans”. Nature Communications 9:1195, https://doi.org/10.1038/s41467-018-03531-2.

87 Apfeld et al. 2004.

88 Tiku, V., et al. 2017. “Small Nucleoli Are a Cellular Hallmark of Longevity”. Nature Communications 8:16083, https://doi.org/10.1038/ncomms16083.