Страница 176
22 июля 2026, 01:4732 Glück, S., et al. 2017. “I
33 De Cecco, M., et al. 2019. “L1 Drives IFN in Senescent Cells and Promotes Age-Associated Inflammation”. Nature 566:73–78, https://doi.org/10.1038/s41586-018-0784-9.
34 Ermolaeva et al. 2013.
35 Coppé, J. P., Desprez, P. Y., Krtolica, A., Campisi, J. 2010. “The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression”. A
36 Terlecki-Zaniewicz, L., et al. 2018. “Small Extracellular Vesicles and Their miRNA Cargo Are Antiapoptotic Members of the Senescence-Associated Secretory Phenotype”. Aging (Albany NY) 10:1103–32, https://doi.org/10.18632/aging.101452.
37 Wiley, C. D., et al. 2017. “Analy sis of Individual Cells Identifies Cell-to-Cell Variability following Induction of Cellular Senescence”. Aging Cell 16:1043–50, https://doi.org/10.1111/acel.12632.
38 Zhu, Y., et al. 2015. “The Achilles’ Heel of Senescent Cells: From Transcriptome to Senolytic Drugs”. Aging Cell 14:644–58, https://doi.org/10.1111/acel.12344; Martel, J., et al. 2020. “Emerging Use of Senolytics and Senomorphics against Aging and Chronic Diseases”. Medicinal Research Reviews 40:2114–31, https://doi.org/10.1002/med.21702; Schafer, M. J., Haak, A. J., Tschumperlin, D. J., LeBrasseur, N. K. 2018. “Targeting Senescent Cells in Fibrosis: Pathology, Paradox, and Practical Considerations”. Current Rheumatology Reports 20:3, https://doi.org/10.1007/s11926-018-0712-x.
39 Jones, M. W., Brett, K., Han, N., Wyatt, H. A. 2021. “Hyperbaric Physics”. StatPearls. Treasure Island, FL: StatPearls.
40 Kamran, P., et al. 2013. “Parabiosis in Mice: A Detailed Protocol”. Journal of Visualized Experiments, no. 80, e50556, https://doi.org/10.3791/50556.
41 Kosoff, M. 2016. “Peter Thiel Wants to Inject Himself with Young People’s Blood”. Vanity Fair, August 1, 2016, https://www.vanityfair.com/news/2016/08/peter-thiel-wants-to-inject-himself-with-young-peoples-blood; Buhr, S. 2017. “No, Peter Thiel Is Not Harvesting the Blood of the Young”. TechCrunch, June 14, 2017, https://techcrunch.com/2017/06/14/ no peter-thiel-is-not-harvesting-the-blood-of-the-young/; Haynes, G. 2017. “Ambrosia: The Startup Harvesting the Blood of the Young”. Guardian, August 21, 2017, https://www.theguardian.com/society/shortcuts/2017/aug/21/ambrosia-the-startup-harvesting-the-blood-of-the-young; “The Blood Boy”. Silicon Valley, season 4, episode 5 (HBO, 2017).
42 Ludwig, F. C., Elashoff, R. M. 1972. “Mortality in Syngeneic Rat Parabionts of Different Chronological Age”. Transactions of the New York Academy of Sciences 34:582–87, https://doi.org/10.1111/j.2164–0947.1972.tb02712.x.
43 Wagers, A. J., Sherwood, R. I., Christensen, J. L., Weissman, I. L. 2002. “Little Evidence for Developmental Plasticity of Adult Hematopoietic Stem Cells”. Science 297:2256–59, https://doi.org/10.1126/science.1074807.
44 Conboy, I. M., et al. 2005. “Rejuvenation of Aged Progenitor Cells by Exposure to a Young Systemic Environment”. Nature 433:760–64, https://doi.org/10.1038/nature03260.
45 Zhang, B., et al. 2021. “Multi-omic Rejuvenation and Lifespan Extension upon Exposure to Youthful Circulation”. bioRxiv, 2021.11.11.468258, https://doi.org10.1101/2021.11.11.468258.
46 Loffredo, F. S., et al. 2013. “Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy”. Cell 153:828–39, https://doi.org/10.1016/j.cell.2013.04.015.
47 Elabd, C., et al. 2014. “Oxytocin Is an Age-Specific Circulating Hormone that Is Necessary for Muscle Maintenance and Regeneration”. Nature Communications 5:4082, https://doi.org/10.1038/ncomms5082; Saito, Y., et al. 1998. “Klotho Protein Protects against Endothelial Dysfunction”. Biochemical and Biophysical Research Communications 248:324–29, https://doi.org/10.1006/bbrc.1998.8943; Zhou, Y., et al. 2021. “Integration of FGF21 Signaling and Metabolomics in High-Fat Diet-Induced Obesity”. Journal of Proteome Research 20:3900–3912, https://doi.org/10.1021/acs.jproteome.1c00197.
48 Villeda, S. A., et al. 2011. “The Ageing Systemic Milieu Negatively Regulates Neurogenesis and Cognitive Function”. Nature 477:90–94, https://doi.org/10.1038/nature10357.
49 Villeda, S. A., et al. 2014. “Young Blood Reverses Age-Related Impairments in Cognitive Function and Synaptic Plasticity in Mice”. Nature Medicine 20:659–63, https://doi.org/10.1038/nm.3569.
50 Castellano, J. M., et al. 2017. “Human Umbilical Cord Plasma Proteins Revitalize Hippocampal Function in Aged Mice”. Nature 544:488–92, https://doi.org/10.1038/nature220 67.
51 Horowitz, A. M., et al. 2020. “Blood Factors Transfer Beneficial Effects of Exercise on Neurogenesis and Cognition to the Aged Brain”. Science 369:167–73, https://doi.org/10.1126/science.aaw2622.
Глaвa 11. Используй или потеряешь
1 Kluger, J. 2013. “Too Old to Be a Dad?” Time, April 11, 2013, https://healthland.time.com/2013/04/11/too-old-to-be-a-dad/.
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