Страница 184
22 июля 2026, 01:4725 Wood, J. G., et al. 2004. “Sirtuin Activators Mimic Caloric Restriction and Delay Ageing in Metazoans”. Nature 430:686–89, https://doi.org/10.1038/nature02789; Valenzano, D. R., et al. 2006. “Resveratrol Prolongs Lifespan and Retards the Onset of Age-Related Markers in a Short-Lived Vertebrate”. Current Biology 16:296–300, https://doi.org/10.1016/j.cub.2005.12.038; Baur, J. A., et al. 2006. “Resveratrol Improves Health and Survival of Mice on a High-Calorie Diet”. Nature 444:337–42, https://doi.org/10.1038/nature05354; Fischer, N., et al. 2017. “The Resveratrol Derivatives Trans-3,5-dimethoxy-4-fluoro-4’ – hydroxystilbene and Trans-2,4’,5-trihydroxystilbene Decrease Oxidative Stress and Prolong Lifespan in Caenorhabditis elegans”. Journal of Pharmacy and Pharmacology 69:73–81, https://doi.org/10.1111/jphp.12657.
26 Hubbard, B. P., et al. 2013. “Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators”. Science 339:1216–19, https://doi.org/10.1126/science.1231097.
27 Bass, T. M., Weinkove, D., Houthoofd, K., Gems, D., Partridge, L. 2007. “Effects of Resveratrol on Lifespan in Drosophila melanogaster and Caenorhabditis elegans”. Mechanisms of Ageing and Development 128:546–52, https://doi.org/10.1016/j.mad.2007.07.007; Burnett, C., et al. 2011. “Absence of Effects of Sir2 Overexpression on Lifespan in C. elegans and Drosophila”. Nature 477:482–85, https://doi.org/10.1038/nature10296.
28 Bieganowski, P., Bre
29 Timmerman, L. 2013. “GlaxoSmithKline Shuts Down Sirtris, Five Years after $ 720M Buyout”. Xconomy, March 12, 2013, https://xconomy.com/boston/2013/03/12/glaxosmithkline-shuts-down-sirtris-five-years-after-720m-buyout/.
30 Extra Credits, 2018. “Pellagra – a Medical Mystery – Extra History”. YouTube, July 26, 2018, https://www.youtube.com/watch?v =reYKBgdrZsM.
31 Taber, S. (@SarahTaber_bww), 2021. “The pellagra epidemic came down to the basic fabric of society”. Twitter, July 10, 2021, 2:28 a.m., https://twitter.com/SarahTaber_ bww/status/1413671334853423107.
32 Imai, S., Armstrong, C. M., Kaeberlein, M., Guarente, L. 2000. “Transcriptional Silencing and Longevity Protein Sir2 is an NAD – Dependent Histone Deacetylase”. Nature 403:795–800, https://doi.org/10.1038/ 35001622.
33 Palmer, R. D., Elnashar, M. M., Vaccarezza, M. 2021. “Precursor Comparisons for the Upregulation of Nicotinamide Adenine Dinucleotide: Novel Approaches for Better Aging”. Aging Medicine 4:214–20, https://doi.org/10.1002/agm2.12170; Life Biosciences, n.d., “Jumpstart Fertility – Reversing Reproductive Decline”. Lifespan.io: Crowdsourcing the Cure for Aging, accessed December 21, 2022, https://www.lifespan.io/road-maps/the-rejuvenation-roadmap/jumpstart-fertility-dna-repair.
34 Horowitz, A. M., et al. 2020. “Blood Factors Transfer Beneficial Effects of Exercise on Neurogenesis and Cognition to the Aged Brain”. Science 369:167–73, https://doi.org/10.1126/science.aaw2622.
35 Coppé, J. P., Desprez, P. Y., Krtolica, A., Campisi, J. 2010. “The Senescence- Associated Secretory Phenotype: The Dark Side of Tumor Suppression”. A
36 Kim, E.-C., Kim, J.-R. 2019. “Senotherapeutics: Emerging Strategy for Healthy Aging and Age-Related Disease”. BMB Reports 52:47–55, https://doi.org/10.5483/BMBRep.2019.52.1.293.
37 Atzmon, G., et al. 2010. “Genetic Variation in Human Telomerase Is Associated with Telomere Length in Ashkenazi Centenarians”. Proceedings of the National Academy of Sciences of the USA 107:1710–17, https://doi.org/10.1073/pnas.0906191106.
38 Zhang, C., et al. 2018. “KMT2A Promotes Melanoma Cell Growth by Targeting hTERT Signaling Pathway”. Cell Death and Disease 8: e2940, https://doi.org/10.1038/cddis.2017.285; Reyes-Uribe, P., et al. 2018. “Exploiting TERT De pendency as a Therapeutic Strategy for NRAS-Mutant Melanoma”. Oncogene 37:4058–72, https://doi.org/10.1038/s41388-018-0247-7.
39 Swain, F. 2019. “Buyer Beware of This $ 1 Million Gene Therapy for Aging”. MIT Technology Review, December 6, 2019, https://www.technologyreview.com/2019/12/06/131657/buyer-beware-of-this-1-million-gene-therapy-for-aging/; Mullin, E. 2019. “Scientists Dodge FDA to Offer a $ 1 Million Anti-aging Treatment in Colombia”. OneZero, December 5, 2019, https://onezero.medium.com/scientists-dodge-fda-to-offer-a-1-million-anti-aging-treatment-in-colombia-38756dfb3ad1.
40 Lewis, R. 2019. “Gene Therapy Update: Remembering Jesse Gelsinger”. DNA Science (blog), September 26, 2019, https://dnascience.plos.org/2019/09/26/gene-therapy-update-remembering-jesse-gelsinger/.
41 Journal of Clinical Investigation. 2008. “Why Gene Therapy Caused Leukemia in Some ‘Boy in the Bubble Syndrome’ Patients”. ScienceDaily, August 10, 2008, https://www.sciencedaily.com/releases/2008/08/080807175438.htm.
42 Нaционaльнaя медицинскaя библиотекa США, 2022. “Gene Therapy for APOE4 Homozygote of Alzheimer’s Disease”. ClinicalTrials.gov, id: NCT03634007, последнее обновление 2 декaбря 2022, https://clinicaltrials.gov/ct2/show/NCT03634007.
43 Нaционaльнaя медицинскaя библиотекa США, 2022. “Double-Blind, Multicenter, Sham Surgery Controlled Study of CERE-120 in Subjects with Idiopathic Parkinson’s Disease”. ClinicalTrials.gov, id: NCT00400634, последнее обновление 10 ноября 2022 г., https://clinicaltrials.gov/ct2/show/NCT00400634.
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