Страница 168

29 Ogg, S., Ruvkun, G. 1998. “The C. elegans PTEN Homolog, DAF-18, Acts in the Insulin Receptor-like Metabolic Signaling Pathway”. Molecular Cell 2:887–93.

30 Paradis, S., Ailion, M., Toker, A., Thomas, J. H., Ruvkun, G. 1999. “A PDK1 Homolog Is Necessary and Sufficient to Transduce AGE-1 PI3 Kinase Signals that Regulate Diapause in Caenorhabditis elegans”. Genes and Development 13:1438–52; Paradis, S., Ruvkun, G. 1998. “Caenorhabditis elegans Akt/PKB Transduces Insulin Receptor-like Signals from AGE-1 PI3 Kinase to the DAF-16 Transcription Factor”. Genes and Development 12:2488–98.

31 Рaсскaзчик из телесериaлa “Остaновкa рaзвития” (Arrested Development): “Это не тaк!”

32 Dillin, A., Crawford, D. K., Kenyon, C. 2002. “Timing Requirements for Insulin/IGF-1 Signaling in C. elegans”. Science 298:830–34.

33 Lakowski, B., Hekimi, S. 1996. “Determination of Life-Span in Caenorhabditis elegans by Four Clock Genes”. Science 272:1010–13; Lakowski, B., Hekimi, S. 1998. “The Genetics of Caloric Restriction in Caenorhabditis elegans”. Proceedings of the National Academy of Sciences of the USA 95:13091–96.

34 Tatar, M., et al. 2001. “A Mutant Drosophila Insulin Receptor Homolog that Extends Life-Span and Impairs Neuroendocrine Function”. Science 292:107–10, https://doi.org/10.1126/science.1057987; Clancy, D. J., et al. 2001. “Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein”. Science 292:104–6, https://doi.org/10.1126/science.1057991.

35 Hwangbo, D. S., Gersham, B., Tu, M. P., Palmer, M., Tatar, M. 2004. “Drosophila dFOXO Controls Lifespan and Regulates Insulin Signalling in Brain and Fat Body”. Nature 429:562–66.

36 Fire, A., et al. 1998. “Potent and Specific Genetic Interference by Double-Stranded RNA in Caenorhabditis elegans”. Nature 391:806–11, https://doi.org/10.1038/35888.

37 Fraser, A. G., et al. 2000. “Functional Genomic Analysis of C. elegans Chromosome I by Systematic RNA Interference”. Nature 408:325–30, https://doi.org/10.1038/35042517.

38 Hansen, M., Hsu, A. L., Dillin, A., Kenyon, C. 2005. “New Genes Tied to Endocrine, Metabolic, and Dietary Regulation of Lifespan from a Caenorhabditis elegans Genomic RNAi Screen”. PLOS Genetics 1:119–28, https://doi.org/10.1371/journal.pgen.0010017; Timmons, L., Tabara, H., Mello, C. C., Fire, A. Z. 2003. “Inducible Systemic RNA Silencing in Caenorhabditis elegans”. Molecular Biology of the Cell 14:2972–83, https://doi.org/10.1091/mbc.e03-01-0858.

39 Stroustrup, N., et al. 2013. “The Caenorhabditis elegans Lifespan Machine”. Nature Methods 10:665–70, https://doi.org/10.1038/nmeth.2475; Churgin, M. A., et al. 2017. “Longitudinal Imaging of Caenorhabditis elegans in a Microfabricated Device Reveals Variation in Behavioral Decline during Aging”. eLife 6: e26652, https://doi.org/10.7554/eLife. 26652; Zhang, W. B., et al. 2016. “Extended Twilight among Isogenic C. elegans Causes a Disproportionate Scaling between Lifespan and Health”. Cell Systems 3:333–45.e334, https://doi.org/10.1016/j.cels.2016.09.003.

40 Kaletsky, R., et al. 2018. “Transcriptome Analysis of Adult Caenorhabditis elegans Cells Reveals Tissue-Specific Gene and Isoform Expression”. PLOS Genetics 14: e1007559, https://doi.org/10.1371/journal.pgen.1007559; Yao, V., et al. 2018. “An Integrative Tissue-Network Approach to Identify and Test Huma n Disease Genes”. Nature Biotechnology, https://doi.org/10.1038/nbt.4246.

41 Mattison, J. A., et al. 2017. “Caloric Restriction Improves Health and Survival of Rhesus Monkeys”. Nature Communications 8:14063, https://doi.org/10.1038/ncomms14063.

42 Salmon, A. B. 2016. “Moving Toward ‘Common’ Use of the Marmoset as a Non-human Primate Aging Model”. Pathobiology of Aging and Age-Related Diseases 6:32758, https://doi.org/10.3402/pba.v6.32758.

43 Hansen, M., Hsu, A. L., Dillin, A., Kenyon, C. 2005. “New Genes Tied to Endocrine, Metabolic, and Dietary Regulation of Lifespan from a Caenorhabditis elegans Genomic RNAi Screen”. PLOS Genetics 1:119–28, https://doi.org/10.1371/journal.pgen.0010017; Dillin, A., et al. 2002. “Rates of Behavior and Aging Specified by Mitochondrial Function during Development”. Science 298:2398–2401, https://doi.org/10.1126/science.1077780; Lee, S. S., et al. 2003. “A Systematic RNAi Screen Identifies a Critical Role for Mitochondria in C. elegans Longevity”. Nature Genetics 33:40–48, https://doi.org/10.1038/ng1056.

44 Powers, R. W., 3rd, Kaeberlein, M., Caldwell, S. D., Ke

45 Shi, C., et al. 2020. “Allocation of Gene Products to Daughter Cells Is Determined by the Age of the Mother in Single Escherichia coli Cells”. Proceedings of the Royal Society B: Biological Sciences 287:20200569, https://doi.org/10.1098/rspb.2020.0569; Aguilaniu, H., Gustafsson, L., Rigoulet, M., Nyström, T. 2003. “Asymmetric Inheritance of Oxidatively Damaged Proteins during Cytokinesis”. Science 299:1751–53, https://doi.org/10.1126/science.1080418.

46 Yang, J., et al. 2015. “Systematic Analysis of Asymmetric Partitioning of Yeast Proteome between Mother and Daughter Cells Reveals «Aging Factors» and Mechanism of Lifespan Asymmetry”. Proceedings of the National Academy of Science s of the USA 112:11977–82, https://doi.org/10.1073/pnas.1506054112.

47 Henderson, K. A., Hughes, A. L., Gottschling, D. E. 2014. “Mother-Daughter Asymmetry of pH Underlies Aging and Rejuvenation in Yeast”. eLife 3: e03504, https://doi.org/10.7554/eLife.03504.

48 Valenzano, D. R., Sharp, S., Brunet, A. 2011. “Transposon-Mediated Transgenesis in the Short-Lived African Killifish Nothobranchius furzeri, a Vertebrate Model for Aging”. G3: Genes|Genomes|Genetics 1:531–38, https://doi.org/10.1534/g3.111.001271.

49 Valenzano, D. R., et al. 2015. “The African Turquoise Killifish Genome Provides Insights into Evolution and Genetic Architecture of Lifespan”. Cell 163:1539–54, https://doi.org/10.1016/j.cell.2015.11.008; Harel, I., Valenzano, D. R., Brunet, A. 2016. “Efficient Genome Engineering Approaches for the Short-Lived African Turquoise Killifish”. Nature Protocols 11:2010–28, https://doi.org/10.1038/nprot.2016.103; Harel, I., et al. 2015. “A Platform for Rapid Exploration of Aging and Diseases in a Naturally Short-Lived Vertebrate”. Cell 160:1013–26, https://doi.org/10.1016/j.cell.2015.01.038.

50 McKay, A., et al. 2021, “An Automated Feeding System for the African Killifish Reveals Effects of Dietary Restriction on Lifespan and Allows Scalable Assessment of Associative Learning”. bioRxiv 2021.03.30:437790, https://doi.org/10.1101/2021.03.30.437790.