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19 Willcox, B. J., et al. 2008. “FOXO3A Genotype Is Strongly Associated with Human Longevity”. Proceedings of the National Academy of Sciences of the USA 105:13987–92, https://doi.org/10.1073/pnas.0801030105; Anselmi, C. V., et al. 2009. “Association of the FOXO3A Locus with Extreme Longevity in a Southern Italian Centenarian Study”. Rejuvenation Research 12:95–104, https://doi.org/10.1089/rej.2008.0827; Flachsbart, F., et al. 2009. “Association of FOXO3A Variation with Human Longevity Confirmed in German Centenarians”. Proceedings of the National Academy of Sciences of the USA 106:2700–2705, https://doi.org/10.1073/pnas.0809594106.

20 Suh, Y., et al. 2008. “Functionally Significant Insulin-like Growth Factor I Receptor Mutations in Centenarians”. Proceedings of the National Academy of Science s of the USA 105:3438–42.

21 Teumer, A., et al. 2016. “Genomewide Meta-analysis Identifies Loci Associated with IGF-I and IGFBP-3 Levels with Impact on Age-Related Traits”. Aging Cell 15:811–24, https:// doi.org/10.1111/acel.12490.

22 Joshi et al. 2017.

23 Lopez-Otin, C., Blasco, M. A., Partridge, L., Serrano, M., Kroemer, G. 2013. “The Hallmarks of Aging”. Cell 153:1194–217, https://doi.org/10.1016/j.cell.2013.05.039.

24 Joshi et al. 2017.

25 Andriani, G. A., et al. 2016. “Whole Chromosome Instability Induces Senescence and Promotes SASP”. Scientific Reports 6:35218, https://doi.org/10.1038/srep35218.

26 Zeng, Y., et al. 2016. “Novel Loci and Pathways Significantly Associated with Longevity”. Scientific Reports 6:21243, https://doi.org/10.1038/srep21243.

27 Zeng, Y., et al. 2016. “Interaction between the FOXO1A-209 Genotype and Tea Drinking Is Significantly Associated with Reduced Mortality at Advanced Ages”. Rejuvenation Research 19, 195–203, https://doi.org/10.1089/rej.2015.1737.

28 Harmon, A. 2017. “The Secret to Long Life? It May Lurk in the DNA of the Oldest among Us”. New York Times, November 13, 2017, https://www.nytimes.com/2017/11/13/health/supercentenarians-genetics-longevity.html.

29 Betterhumans Inc. “Collaborate with Betterhumans”. Betterhumans Supercentenarian Research Study, 2022, https://supercentenarianstudy.com/collaborate.html.

30 Garagnani, P., et al. 2021. “Whole-Genome Sequencing Analy sis of Semi- supercentenarians”. eLife 10: e57849, https://doi.org/10.7554/eLife.57849.

31 Teumer et al. 2016; Johnson, S. C., Dong, X., Vijg, J., Suh, Y. 2015. “Genetic Evidence for Common Pathways in Human Age-Related Diseases”. Aging Cell 14:809–17, https://doi.org/10.1111/acel.12362.

32 Fortney, K., et al. 2015. “Genome-wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity”. PLOS Genetics 11: e1005728, https://doi.org/10.1371/journal.pgen.1005728.

33 Ruby, J. G., et al. 2018. “Estimates of the Heritability of Human Longevity Are Substantially Inflated Due to Assortative Mating”. Genetics 210:1109–24, https://doi.org/10.1534/genetics.118.301613.

Глaвa 4. Долгоживущие оргaнизмы и долгоживущие мутaнты модельных оргaнизмов

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